Table of Contents
A single CAR-T cell can carry thousands of receptor proteins, but flow cytometry can't tell you how those proteins are arranged on its surface, where they cluster, or whether the immune synapse will actually form when the cell meets a tumour.
Pixelgen Technologies has built a sequencing-based platform that maps protein organisation on individual immune cells at nanometre resolution, turning single-cell spatial proteomics into something any NGS lab can run.
The Stockholm-based company's Molecular Pixelation (MPX) platform uses DNA-barcoded antibodies to spatially encode protein neighbourhoods on a cell's surface, then reads them out via standard short-read sequencing – no specialised imaging hardware required. The result is single-cell, 3D-resolved protein maps that show CAR-T developers, immunologists and immuno-oncologists exactly how their target proteins cluster, co-localise and reorganise on individual cells.
At ISCT Dublin 2026, Onyx caught up with the European Business Development Manager of Pixelgen Technologies, Peter Djali, to find out more.
A special thanks to our Onyx Live sponsors:
Cellares – delivering cell therapy manufacturing excellence at scale across a global network of IDMO smart factories https://www.cellares.com/
Comments