✨ Onyx Summary Kyverna Therapeutics announced the launch of an underwritten public offering of $100 million of common stock, with an option for underwriters to purchase up to an additional $15 million of shares, subject to market conditions. The financing is intended to be conducted under Kyverna’s existing shelf registration
✨ Onyx Summary Kyverna Therapeutics reported positive topline data from the registrational Phase 2 KYSA-8 trial showing that mivocabtagene autoleucel (miv-cel), a CD19-targeting CAR T-cell therapy, delivered statistically significant and sustained improvements in mobility, disability, and stiffness in patients with stiff person syndrome after a single dose. The results support Kyverna’
✨ Onyx Summary Kyverna Therapeutics announced it will host a live webcast and conference call on December 15, 2025, to review topline results from the registrational Phase 2 KYSA-8 trial evaluating KYV-101 in patients with stiff person syndrome. EMERYVILLE, Calif., Dec. 14, 2025 – Kyverna Therapeutics, Inc. (Nasdaq: KYTX), a clinical-stage biopharmaceutical
✨ Onyx Summary The European Medicines Agency recommended granting conditional marketing authorization for ImmunityBio’s ANKTIVA in combination with BCG for patients with BCG-unresponsive non-muscle invasive bladder cancer with carcinoma in situ, marking a potential new treatment option where cystectomy is often the only alternative. The recommendation, based on durable complete
✨ Onyx Summary Guardant Health and Trial Library formed a strategic collaboration to integrate precision oncology diagnostics with AI-driven trial matching and navigation to expand access to cancer clinical trials across the United States. The partnership links Guardant’s large-scale biomarker and real-world data with Trial Library’s nationwide clinic network
✨ Onyx Summary Geron Corporation announced a strategic restructuring plan that will reduce its workforce by approximately one-third and is expected to lower full-year 2026 operating expenses below 2025 levels, with savings beginning in the first quarter of 2026. The move reflects a shift toward tighter financial discipline while maintaining focus
✨ Onyx Summary Sinaptica Therapeutics received funding from the Centre for Aging + Brain Health Innovation (CABHI), in partnership with Baycrest, to support development and validation of its personalized, non-invasive neuromodulation system for Alzheimer’s disease. The funding deepens Sinaptica’s collaboration with Baycrest and supports advancement toward clinical readiness and future
✨ Onyx Summary Ocugen said CEO and co-founder Dr. Shankar Musunuri will present at the Oppenheimer Movers in Rare Disease Summit on December 11, 2025, where he will discuss the company’s modifier gene therapy platform and its potential applications in inherited retinal and age-related blindness diseases. The presentation, alongside investor
✨ Onyx Summary Lexicon Pharmaceuticals announced the publication of preclinical data in the Journal of the Endocrine Society validating Acyl-CoA Synthetase 5 (ACSL5) as a therapeutic target for obesity and chronic weight management, supporting advancement of its investigational oral inhibitor LX9851. The findings, combined with Lexicon’s March 2025 worldwide licensing
✨ Onyx Summary Guardant Health launched FPG 360, an in-house liquid biopsy testing service at Policlinico Gemelli in Rome, enabling on-site use of Guardant360 CDx technology for routine care and clinical research within one of Italy’s largest oncology centers. The partnership extends Guardant’s European public-private model by embedding liquid
✨ Onyx Summary Geron presented new ASH 2025 data reinforcing RYTELO (imetelstat) activity in lower-risk MDS and myelofibrosis, including analyses linking early treatment-emergent cytopenias to subsequent hemoglobin gains and transfusion independence in the IMerge program. Updated long-term outcomes from IMerge and biomarker findings from IMbark further support ongoing development of imetelstat
✨ Onyx Summary Recursion reported positive Phase 1b/2 data from the ongoing TUPELO trial showing that REC-4881, an investigational allosteric MEK1/2 inhibitor, delivered rapid and durable reductions in polyp burden in patients with familial adenomatous polyposis, with effects persisting after treatment cessation. The results represent the first clinical validation
✨ Onyx Summary Legend Biotech Corporation reported updated ASH 2025 data showing CARVYKTI® achieved a median progression-free survival of 50.4 months in triple-class-exposed multiple myeloma patients with three prior lines of therapy, with translational analyses indicating stronger immune fitness when used earlier in treatment. The company also presented first-in-human Phase
✨ Onyx Summary Lexicon Pharmaceuticals announced that new clinical data from the SOTA-P-CARDIA trial evaluating the effect of sotagliflozin on adipose tissue distribution in non-diabetic patients with HFpEF will be presented at the 22nd Global Cardio Vascular Clinical Trialists Forum in December 2025. The presentation adds to prior cardiovascular data on
✨ Onyx Summary Guardant Health will present 14 abstracts at the 2025 San Antonio Breast Cancer Symposium (Dec. 9–12, 2025) highlighting data across Guardant Reveal and Guardant360 Liquid that evaluate tissue-free, blood-based testing for minimal residual disease detection, treatment response assessment, relapse risk prediction, and breast cancer subtyping from early-stage
✨ Onyx Summary Perspective Therapeutics announced that updated safety and preliminary efficacy data from its [212Pb]VMT-α-NET program in advanced SSTR2-expressing neuroendocrine tumors have been accepted for presentation at the ASCO Gastrointestinal Cancers Symposium 2026. The accepted abstract builds on previously reported interim results showing a favorable safety profile and early
